Royal Air Force Typhoon FGR4s have operated alongside French warplanes in a coordinated attack on an hidden munitions depot in Syria employed by the Daesh militant organization, per a report from the UK's MoD.
The facility, located using surveillance, was thought to be storing arms and explosives, the statement said, and was situated in hills just above the historic site of Palmyra in Syria's central region.
"Our fighter planes utilized precision-guided Paveway IV munitions to target a several access tunnels providing entry to the depot... initial indications indicate the objective was successfully hit," the ministry announced.
There was no indication of any harm to civilians in the operation late on Saturday and all the aircraft made a safe return, the MoD added.
The British jets were supported by a Voyager refuelling tanker.
IS - alternatively referred to as ISIS - established jihadist rule over large swathes of Syria and Iraq prior to its 2019 collapse.
"This operation shows the UK's leading role, and resolve to operate in unison with our allies, to stamp out any re-emergence of IS and their dangerous and violent ideologies in the region," the British Defence Secretary the Defence Secretary said.
RAF aircraft have performed surveillance missions over Syria to "forestall any attempted resurgence" of Islamic State following its military defeat at the Baghuz confrontation in 2019, the authorities noted.
"I must thank all the members of British forces participating in this strike for their professionalism and their bravery," the Defence Secretary added. "Including them were thousands of British personnel deployed over the holidays. This mission, to remove militants who pose a risk to our security, demonstrates how our armed forces are prepared to act, all year round, protecting the UK within its borders and influential overseas."
In December, the US military carried out what it termed a "large-scale strike" on Daesh sites in the country, after an ambush claimed the lives of two US troops and a civilian interpreter in the Palmyra area.
The United Nations estimates IS still has between 5,000 and 7,000 combatants in both countries.
